Acetyl Tetrapeptide-5 vs Palmitoyl Pentapeptide-4 at a glance
Acetyl Tetrapeptide-5
Palmitoyl Pentapeptide-4
Type
Key active
Key active
What it is
Anti-edema / anti-puffiness peptide
Anti-aging signal peptide
Flags
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Acetyl Tetrapeptide-5
Acetyl Tetrapeptide-5 is a synthetic peptide used in cosmetics primarily to reduce periorbital puffiness and improve skin elasticity by inhibiting angiotensin-converting enzyme activity and reducing fluid accumulation and glycation. It is commonly found in eye creams and anti-aging formulations.
Palmitoyl Pentapeptide-4 (Matrixyl, pal-KTTKS) is a lipidated peptide that signals fibroblasts to increase production of collagen, elastin, and other extracellular matrix components. It is used in topical formulations to help reduce the appearance of fine lines and improve skin firmness.
What is the difference between Acetyl Tetrapeptide-5 and Palmitoyl Pentapeptide-4?
Acetyl Tetrapeptide-5: Acetyl Tetrapeptide-5 is a synthetic peptide used in cosmetics primarily to reduce periorbital puffiness and improve skin elasticity by inhibiting ang Palmitoyl Pentapeptide-4: Palmitoyl Pentapeptide-4 (Matrixyl, pal-KTTKS) is a lipidated peptide that signals fibroblasts to increase production of collagen, elastin, and other
Which is better for my skin, Acetyl Tetrapeptide-5 or Palmitoyl Pentapeptide-4?
Neither is universally better — it depends on your skin type, tolerance and what else is in your routine. The flags above (fungal-acne, pore-clogging, fragrance, pregnancy) are the objective differences; a dermatologist can weigh them for your skin.
Can I use Acetyl Tetrapeptide-5 and Palmitoyl Pentapeptide-4 together?
Check the compatibility verdict linked on this page, or run your full routine through the routine checker before combining actives.
General educational information for Indian skin, compiled from published dermatology literature and structured ingredient data. Not medical advice or a diagnosis.