Comparison

Acetyl Tetrapeptide-5 vs Palmitoyl Tripeptide-1

Acetyl Tetrapeptide-5 vs Palmitoyl Tripeptide-1 at a glance

 Acetyl Tetrapeptide-5Palmitoyl Tripeptide-1
TypeKey activeKey active
What it isAnti-edema / anti-puffiness peptideSignal peptide / anti-aging active
Flags

Acetyl Tetrapeptide-5

Acetyl Tetrapeptide-5 is a synthetic peptide used in cosmetics primarily to reduce periorbital puffiness and improve skin elasticity by inhibiting angiotensin-converting enzyme activity and reducing fluid accumulation and glycation. It is commonly found in eye creams and anti-aging formulations.

Full Acetyl Tetrapeptide-5 profile →

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-1 is a synthetic palmitoylated peptide (sequence Gly-His-Lys) used in cosmetics to signal fibroblasts and support collagen and extracellular matrix synthesis. It is commonly combined with other peptides in anti-aging and firming formulations.

Full Palmitoyl Tripeptide-1 profile →

Frequently asked

What is the difference between Acetyl Tetrapeptide-5 and Palmitoyl Tripeptide-1?
Acetyl Tetrapeptide-5: Acetyl Tetrapeptide-5 is a synthetic peptide used in cosmetics primarily to reduce periorbital puffiness and improve skin elasticity by inhibiting ang Palmitoyl Tripeptide-1: Palmitoyl Tripeptide-1 is a synthetic palmitoylated peptide (sequence Gly-His-Lys) used in cosmetics to signal fibroblasts and support collagen and ex
Which is better for my skin, Acetyl Tetrapeptide-5 or Palmitoyl Tripeptide-1?
Neither is universally better — it depends on your skin type, tolerance and what else is in your routine. The flags above (fungal-acne, pore-clogging, fragrance, pregnancy) are the objective differences; a dermatologist can weigh them for your skin.
Can I use Acetyl Tetrapeptide-5 and Palmitoyl Tripeptide-1 together?
Check the compatibility verdict linked on this page, or run your full routine through the routine checker before combining actives.

General educational information for Indian skin, compiled from published dermatology literature and structured ingredient data. Not medical advice or a diagnosis.