Ceramide 6 II (a phytosphingosine-based ceramide, also known as ceramide AP) is a naturally occurring skin lipid used in skincare to help restore and reinforce the stratum corneum barrier and reduce transepidermal water loss. It is typically incorporated as part of physiological lipid blends to support hydration and skin barrier function.
| Reported effect | How often | Notes |
|---|---|---|
Mild transient irritation or stinging | Rare | Occasionally reported, often related to other formulation components rather than the ceramide itself. |
Allergic contact dermatitis | Very rare | Ceramides are skin-identical lipids and are generally well tolerated; sensitization is uncommon. |
Redness or localized reaction | Very rare | Isolated reports, typically associated with overall product formulation. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
Peer-reviewed papers on this ingredient, via PubMed.