Lipase is an enzyme that catalyzes the hydrolysis of lipids (fats and oils) into fatty acids and glycerol, and is occasionally used in skincare for gentle enzymatic exfoliation or to modify lipid-based formulations. Its activity depends on appropriate pH, temperature, and water content to remain functional.
| Reported effect | How often | Notes |
|---|---|---|
Skin irritation (redness, stinging) | Uncommon | More likely with higher concentrations or compromised skin barrier. |
Allergic contact dermatitis | Rare | Enzymes are recognized sensitizers; reactions documented mainly in occupational settings. |
Respiratory sensitization on inhalation | Rare | Relevant to aerosolized/powder forms; documented occupational hazard with proteolytic and lipolytic enzymes. |
Severe immediate hypersensitivity (urticaria/anaphylaxis) | Very rare | Reported with enzyme exposure in sensitized individuals. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.