Dipeptide-2 (valyl-tryptophan) is a synthetic dipeptide used in cosmetic formulations, primarily in eye and anti-puffiness products, where it is claimed to help reduce fluid accumulation and improve the appearance of under-eye bags by supporting lymphatic drainage. Evidence is largely manufacturer-based, with limited independent clinical data.
| Reported effect | How often | Notes |
|---|---|---|
| Localized irritation or redness | Rare | Mild transient reaction reported at application site, generally formulation-dependent. |
| Allergic contact dermatitis | Very rare | Possible sensitization to peptide or accompanying excipients; not well documented. |
| Stinging or burning sensation | Rare | Typically mild and resolving, more common on sensitive or compromised skin. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.