Grape seed extract is a polyphenol-rich botanical extract (notably proanthocyanidins) used in skincare for its antioxidant and free-radical scavenging properties, which may help protect against oxidative and UV-related skin damage. It is also valued for potential anti-inflammatory and skin-conditioning effects.
| Reported effect | How often | Notes |
|---|---|---|
| Contact irritation | Uncommon | Mild redness or stinging possible, particularly in sensitive skin or at higher concentrations. |
| Allergic contact dermatitis | Rare | Sensitization to plant polyphenols or grape-derived components has been reported in isolated cases. |
| Cross-reactivity in grape-allergic individuals | Very rare | Theoretical risk in those with known grape or related botanical allergies. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
Peer-reviewed papers on this ingredient, via PubMed.