Methylsulfonylmethane (MSM) is an organosulfur compound used topically for its anti-inflammatory and skin-conditioning properties, often included in formulations targeting redness, irritation, and signs of aging. It may also enhance skin permeability of co-formulated ingredients.
| Reported effect | How often | Notes |
|---|---|---|
| Mild skin irritation or stinging | Uncommon | Transient and typically resolves with discontinuation. |
| Redness or erythema at application site | Uncommon | Usually mild and temporary. |
| Contact dermatitis / allergic reaction | Rare | Sensitization is infrequently reported. |
| Itching or pruritus | Rare | May occur in sensitive individuals. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.