Nicotinamide (niacinamide) is a water-soluble form of vitamin B3 used topically to support the skin barrier, regulate sebum, reduce hyperpigmentation, and improve signs of aging. It is generally well tolerated across a range of concentrations.
| Reported effect | How often | Notes |
|---|---|---|
| Mild transient stinging or tingling | Uncommon | Usually brief, more likely at higher concentrations or on compromised skin. |
| Redness or erythema | Uncommon | Typically mild and temporary, often dose-dependent. |
| Itching or burning sensation | Rare | Generally resolves with discontinuation. |
| Contact dermatitis or allergic reaction | Rare | Documented in isolated cases; patch testing can confirm sensitivity. |
| Facial flushing | Very rare | More associated with oral niacin; topical nicotinamide rarely causes flushing. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.