Polyhydroxy acids (PHAs) such as gluconolactone and lactobionic acid are larger-molecule acids that gently exfoliate the skin surface while providing humectant and antioxidant benefits. Their larger molecular size limits deep penetration, making them milder than alpha-hydroxy acids and generally suitable for sensitive skin.
| Reported effect | How often | Notes |
|---|---|---|
| Mild transient stinging or tingling | Common | Brief sensation on application, especially on compromised skin |
| Skin dryness or scaling | Uncommon | More likely with frequent use or higher concentrations |
| Erythema (redness) | Uncommon | Usually mild and temporary |
| Increased photosensitivity | Uncommon | Less pronounced than with AHAs; sunscreen still advised |
| Allergic or irritant contact dermatitis | Rare | Reported in sensitized individuals |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
Peer-reviewed papers on this ingredient, via PubMed.