sh-Polypeptide-123 is a synthetic (recombinant/synthesized) human-identical peptide used in skincare to signal fibroblasts and support collagen and extracellular matrix production. It is marketed primarily for anti-aging and skin-repair applications.
| Reported effect | How often | Notes |
|---|---|---|
Mild transient redness or irritation at application site | Uncommon | Usually resolves shortly after application; more likely in sensitive skin or with higher concentrations. |
Contact dermatitis / allergic sensitization | Rare | Peptide or accompanying formulation components may trigger allergic response in predisposed individuals. |
Stinging or itching | Uncommon | Often related to other formulation ingredients rather than the peptide itself. |
Theoretical concern regarding growth-factor stimulation | Very rare | Limited long-term data; caution sometimes advised for individuals with active skin lesions, though clinical evidence of harm is lacking. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.