Sh-Polypeptide-22 is a synthetic recombinant peptide corresponding to a human growth factor (often associated with thrombopoietin-related or signaling fragments) used in cosmetic formulations to support skin repair, collagen synthesis, and barrier function. It functions as a cell-signaling active intended to improve signs of aging and skin recovery.
| Reported effect | How often | Notes |
|---|---|---|
| Mild transient redness or irritation at application site | Uncommon | Generally resolves shortly after application; more likely in sensitive skin. |
| Contact allergic sensitization | Rare | Possible due to peptide or accompanying formulation components; presents as localized dermatitis. |
| Itching or stinging | Uncommon | Typically transient and associated with compromised skin barrier. |
| Theoretical concern regarding growth factor stimulation | Very rare | Limited long-term clinical data; caution sometimes advised for use over abnormal or precancerous lesions, though evidence is lacking. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.