SH-Polypeptide-9 is a synthetic form of vascular endothelial growth factor (VEGF) used in cosmetics to support skin repair, angiogenesis-related processes, and overall skin rejuvenation. It is typically incorporated into anti-aging and recovery formulations to promote tissue regeneration.
| Reported effect | How often | Notes |
|---|---|---|
| Mild transient irritation or redness | Uncommon | Generally localized and resolves shortly after application. |
| Contact sensitization or allergic reaction | Rare | Possible in individuals sensitive to peptide-based ingredients. |
| Theoretical concern regarding angiogenic activity | Very rare | VEGF-related growth factors are debated for potential effects on abnormal cell or vessel proliferation; clinical evidence in topical use is limited. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
Peer-reviewed papers on this ingredient, via PubMed.