Nicotinoyl Tripeptide-35 is a niacin-conjugated synthetic tripeptide used in cosmetic formulations for its purported skin-conditioning, soothing, and anti-aging effects, often marketed to support microcirculation and skin barrier function. It combines a peptide signaling sequence with a nicotinic acid (vitamin B3-related) moiety to enhance bioactivity.
| Reported effect | How often | Notes |
|---|---|---|
Mild transient redness or flushing | Uncommon | Possibly related to the nicotinoyl (niacin) component affecting local vasodilation. |
Localized irritation or stinging | Rare | Typically associated with sensitive skin or high concentrations. |
Contact dermatitis or allergic reaction | Very rare | Peptide or formulation excipient sensitivity; data limited. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.