Azadirachta Indica (Neem) leaf extract is a plant-derived ingredient valued for its antibacterial, anti-inflammatory, and antioxidant properties, often used in acne-prone and irritated skin formulations. Its activity is attributed to compounds such as nimbidin, nimbin, and various flavonoids and terpenoids.
| Reported effect | How often | Notes |
|---|---|---|
Allergic contact dermatitis | Uncommon | Localized redness, itching, or rash in sensitized individuals. |
Skin irritation or stinging | Uncommon | Mild transient irritation, more likely at higher concentrations or on compromised skin. |
Contact urticaria | Rare | Hives reported in isolated sensitivity cases. |
Systemic toxicity from oral/excessive use | Very rare | Associated with ingestion rather than topical cosmetic application. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
Peer-reviewed papers on this ingredient, via PubMed.