Dimethyl Isosorbide (DMI) is a small, polar solvent derived from isosorbide used in cosmetic formulations to dissolve active ingredients and enhance their penetration into the skin. It functions as a vehicle and carrier rather than a therapeutic active itself.
| Reported effect | How often | Notes |
|---|---|---|
Mild skin irritation or stinging | Uncommon | May occur at higher concentrations or on compromised/sensitive skin. |
Increased penetration-related irritation from co-formulated actives | Uncommon | By enhancing delivery, DMI can amplify irritancy of other ingredients in the product. |
Contact dermatitis or allergic sensitization | Rare | Allergic reactions are infrequently reported in the literature. |
Transient erythema (redness) | Rare | Usually mild and self-resolving. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.