SH-Polypeptide-11 is a synthetic recombinant growth factor peptide (related to vascular endothelial growth factor signaling) used in cosmetic formulations to support skin renewal, repair, and microcirculation. It is included in anti-aging and skin-conditioning products for its proposed role in stimulating cellular activity and barrier recovery.
| Reported effect | How often | Notes |
|---|---|---|
Mild transient skin irritation or redness | Uncommon | Localized erythema or stinging shortly after application, typically self-resolving. |
Contact sensitization or allergic dermatitis | Rare | Possible in individuals sensitive to peptide or protein-based ingredients. |
Itching or burning sensation | Rare | Generally mild and transient, more likely on compromised or sensitive skin. |
Theoretical concern over growth-factor effects on abnormal cell proliferation | Very rare | Largely theoretical with topical cosmetic use; clinical evidence is limited and inconclusive. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.