SH-Polypeptide-3 is a synthetic copper-binding tripeptide (also known as copper tripeptide, GHK-Cu) used in skincare for its proposed roles in supporting collagen synthesis, wound healing, and antioxidant activity. It is generally classified as a bioactive signaling ingredient in anti-aging formulations.
| Reported effect | How often | Notes |
|---|---|---|
Mild skin irritation or stinging | Uncommon | Transient sensation at application site, usually resolving quickly. |
Erythema (redness) | Uncommon | Localized redness, more likely in sensitive skin. |
Allergic contact dermatitis | Rare | Hypersensitivity reactions reported infrequently; copper sensitivity may contribute. |
Itching or burning sensation | Rare | Generally mild and temporary. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.