Below is every ingredient in Cell Renewal Collagen-PDRN Serum explained, its standout actives, and the side effects reported in research for those actives — analysed for Indian skin.
Flags derived from the ingredient list using dermatology reference data (fungal-acne substrate, comedogenicity, EU allergens). General guidance, not a diagnosis.
Answers are derived from the printed ingredient list and dermatology reference data — general guidance, not a diagnosis or a therapeutic claim.
Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%.
Centella Asiatica Extract is a plant-derived ingredient rich in triterpenoids (asiaticoside, madecassoside, asiatic and madecassic acids) used to calm inflammation, support wound healing, and strengthen the skin barrier. It is also valued for antioxidant and collagen-supporting properties in topical formulations.
sh-Polypeptide-123 is a synthetic (recombinant/synthesized) human-identical peptide used in skincare to signal fibroblasts and support collagen and extracellular matrix production. It is marketed primarily for anti-aging and skin-repair applications.
Octenidine HCl is a cationic surfactant antiseptic effective against bacteria, fungi, and some viruses, used in skin and wound disinfection and as a preservative in topical formulations. It binds to negatively charged microbial cell membranes, disrupting their integrity.
Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%.
Centella Asiatica Extract is a plant-derived ingredient rich in triterpenoids (asiaticoside, madecassoside, asiatic and madecassic acids) used to calm inflammation, support wound healing, and strengthen the skin barrier. It is also valued for antioxidant and collagen-supporting properties in topical formulations.
Aggregated from the active ingredients in this product.
| Reported effect | How often | Notes |
|---|---|---|
| Irritation or sensitivity | Very rare | Purified water itself is essentially inert; rare reactions are attributable to contaminants or accompanying ingredients rather than water. |
| Transepidermal water loss aggravation in compromised skin | Rare | Evaporation of water from products may transiently increase dryness in very compromised skin barriers if occlusives are absent. |
| Mild transient stinging or irritation | Uncommon | More likely on broken or compromised skin or at high concentrations. |
| Allergic contact dermatitis | Rare | Documented in patch-test studies but considered a relatively weak sensitizer. |
| Redness or itching | Rare | Typically resolves after discontinuation. |
| Mild skin irritation | Uncommon | Transient stinging or redness, more likely on compromised or sensitive skin. |
| Enhanced penetration of co-formulated irritants | Uncommon | As a penetration enhancer it may increase absorption and irritation potential of other actives. |
| Mild transient flushing or redness | Uncommon | More likely at higher concentrations or in sensitive skin; usually subsides quickly. |
| Tingling, stinging, or burning sensation | Uncommon | Often associated with higher percentages or compromised barrier. |
| Contact irritation or itching | Rare | Generally dose-dependent and resolves with discontinuation. |
| Mild transient irritation or stinging | Rare | Generally well tolerated; occasional sensitivity reported, often related to overall formulation. |
| Contact urticaria | Very rare | Isolated reports of immediate hypersensitivity reactions. |
| Eye irritation | Uncommon | Can cause irritation on direct contact with eyes, relevant in eye-area products. |
| Redness or dryness in low-humidity environments | Uncommon | Can draw moisture from skin if ambient humidity is very low and not sealed with an occlusive. |
| Hypersensitivity reactions with injectable forms | Very rare | Relevant mainly to dermal filler use, not topical cosmetic application. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
| Ingredient | What it does |
|---|---|
| Aqua Solvent / vehicle | Aqua (water) is the most common base ingredient in skincare formulations, serving as a solvent that dissolves water-soluble components and forms the medium for emulsions. It has no direct treatment activity and primarily contributes to texture, spreadability, and product delivery. |
| Butylene glycol Humectant / solvent | Butylene glycol is a small diol commonly used in skincare as a humectant, solvent, and viscosity-reducing agent that helps dissolve other ingredients and improve skin feel. It is widely regarded as safe and non-sensitizing for the majority of users at cosmetic concentrations. |
| Propanediol Humectant/solvent | Propanediol is a plant-derived glycol used in skincare as a humectant, solvent, and penetration enhancer that improves moisturization and the spreadability of formulations. It also helps solubilize other ingredients and can boost the efficacy of certain actives. |
| Niacinamide Key active Cell-communicating / barrier-repair active | Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%. |
| Saccharide Isomerate Humectant / moisturizer | Saccharide Isomerate is a plant-derived carbohydrate complex that binds to the skin's keratin to provide long-lasting hydration and improve moisture retention. It is structurally similar to carbohydrates naturally found in the skin's upper layers. |
| Phenoxyethanol Preservative | Phenoxyethanol is a widely used broad-spectrum preservative that protects cosmetic and skincare formulations from bacterial and fungal contamination. It is typically used at concentrations up to 1% and serves as a formulation/base ingredient rather than an active treatment. |
| Sodium Hyaluronate Humectant / hydrator | Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan that attracts and binds water to the skin to improve hydration and surface plumpness. Its lower molecular weight allows better penetration than native hyaluronic acid. |
| Sodium Polyglutamate Humectant / moisturizer | Sodium polyglutamate is the sodium salt of polyglutamic acid, a biopolymer that binds and retains water in the skin, enhancing hydration and the moisturizing performance of formulations. It also forms a light film on the skin surface that can improve smoothness and reduce transepidermal water loss. |
| Sodium DNA Humectant / skin-conditioning agent | Sodium DNA is the sodium salt of deoxyribonucleic acid, typically derived from fish or plant sources, used in cosmetics as a water-binding humectant and conditioning agent that may help maintain skin hydration and barrier integrity. Marketing claims of significant anti-aging or repair effects are largely unsubstantiated by robust clinical evidence. |
| Centella Asiatica Extract Key active Soothing/antioxidant active | Centella Asiatica Extract is a plant-derived ingredient rich in triterpenoids (asiaticoside, madecassoside, asiatic and madecassic acids) used to calm inflammation, support wound healing, and strengthen the skin barrier. It is also valued for antioxidant and collagen-supporting properties in topical formulations. |
| 2-Hexanediol Humectant/preservative-booster | 1,2-Hexanediol (commonly written 2-hexanediol) is a multifunctional diol used in skincare primarily as a humectant, solvent, and preservative-enhancing agent that improves the antimicrobial efficacy of formulations. It is generally well tolerated and considered a base/formulation ingredient rather than a treatment active. |
| sh-Polypeptide-123 Key active Signal peptide / growth factor mimetic | sh-Polypeptide-123 is a synthetic (recombinant/synthesized) human-identical peptide used in skincare to signal fibroblasts and support collagen and extracellular matrix production. It is marketed primarily for anti-aging and skin-repair applications. |
| Sodium Polyacrylate Thickener / absorbent | Sodium polyacrylate is a superabsorbent acrylic-acid polymer used in skincare as a thickening, stabilizing, and water-binding agent that can hold large amounts of liquid to create gel-like textures. It functions as a formulation and texture-enhancing ingredient rather than a biologically active treatment. |
| Ethylhexylglycerin Preservative booster / skin-conditioning agent | Ethylhexylglycerin is a multifunctional glyceryl ether used in cosmetics primarily as a preservative-enhancing agent and emollient, often paired with phenoxyethanol to broaden antimicrobial efficacy. It also acts as a deodorizing agent and humectant in skincare formulations. |
| Octenidine HCl Key active Antiseptic/antimicrobial | Octenidine HCl is a cationic surfactant antiseptic effective against bacteria, fungi, and some viruses, used in skin and wound disinfection and as a preservative in topical formulations. It binds to negatively charged microbial cell membranes, disrupting their integrity. |
| Phytic acid Chelating agent / antioxidant exfoliant | Phytic acid is a plant-derived compound that chelates metal ions and provides mild antioxidant and gentle exfoliating effects, often used in formulations to brighten skin and stabilize products. It is sometimes included in peels and serums as a milder alternative to traditional alpha hydroxy acids. |
| Disodium EDTA Chelating agent | Disodium EDTA is a chelating agent used in cosmetics to bind metal ions, improving product stability, preventing rancidity, and enhancing the efficacy of preservatives. It is a formulation/base ingredient rather than a treatment active. |
| Benzotriazolyl Dodecyl p-Cresol UV stabilizer/antioxidant | Benzotriazolyl Dodecyl P-Cresol is a benzotriazole-derived light stabilizer and antioxidant used in cosmetic formulations to protect product integrity by absorbing UV radiation and preventing oxidative degradation of other ingredients. It functions as a formulation-protecting additive rather than a skin treatment active. |
| Citric acid pH adjuster / AHA exfoliant | Citric acid is an alpha-hydroxy acid derived from citrus fruits, used primarily to adjust and buffer formulation pH and as a chelating agent, and at higher concentrations as a mild chemical exfoliant. It can promote surface cell turnover and is sometimes included in antioxidant or brightening products. |
| Sodium citrate pH adjuster / chelating agent | Sodium citrate is the sodium salt of citric acid used in skincare primarily as a buffering agent to stabilize formulation pH and as a chelator that binds metal ions to improve product stability. It is a base/formulation ingredient rather than a therapeutic active. |
| Butylene glycol Humectant / solvent | Butylene glycol is a small diol commonly used in skincare as a humectant, solvent, and viscosity-reducing agent that helps dissolve other ingredients and improve skin feel. It is widely regarded as safe and non-sensitizing for the majority of users at cosmetic concentrations. |
| Propanediol Humectant/solvent | Propanediol is a plant-derived glycol used in skincare as a humectant, solvent, and penetration enhancer that improves moisturization and the spreadability of formulations. It also helps solubilize other ingredients and can boost the efficacy of certain actives. |
| Niacinamide Key active Cell-communicating / barrier-repair active | Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%. |
| Saccharide Isomerate Humectant / moisturizer | Saccharide Isomerate is a plant-derived carbohydrate complex that binds to the skin's keratin to provide long-lasting hydration and improve moisture retention. It is structurally similar to carbohydrates naturally found in the skin's upper layers. |
| Phenoxyethanol Preservative | Phenoxyethanol is a widely used broad-spectrum preservative that protects cosmetic and skincare formulations from bacterial and fungal contamination. It is typically used at concentrations up to 1% and serves as a formulation/base ingredient rather than an active treatment. |
| Sodium Hyaluronate Humectant / hydrator | Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan that attracts and binds water to the skin to improve hydration and surface plumpness. Its lower molecular weight allows better penetration than native hyaluronic acid. |
| Sodium Polyglutamate Humectant / moisturizer | Sodium polyglutamate is the sodium salt of polyglutamic acid, a biopolymer that binds and retains water in the skin, enhancing hydration and the moisturizing performance of formulations. It also forms a light film on the skin surface that can improve smoothness and reduce transepidermal water loss. |
| Sodium DNA Humectant / skin-conditioning agent | Sodium DNA is the sodium salt of deoxyribonucleic acid, typically derived from fish or plant sources, used in cosmetics as a water-binding humectant and conditioning agent that may help maintain skin hydration and barrier integrity. Marketing claims of significant anti-aging or repair effects are largely unsubstantiated by robust clinical evidence. |
| Centella Asiatica Extract Key active Soothing/antioxidant active | Centella Asiatica Extract is a plant-derived ingredient rich in triterpenoids (asiaticoside, madecassoside, asiatic and madecassic acids) used to calm inflammation, support wound healing, and strengthen the skin barrier. It is also valued for antioxidant and collagen-supporting properties in topical formulations. |
| 2-Hexanediol Humectant/preservative-booster | 1,2-Hexanediol (commonly written 2-hexanediol) is a multifunctional diol used in skincare primarily as a humectant, solvent, and preservative-enhancing agent that improves the antimicrobial efficacy of formulations. It is generally well tolerated and considered a base/formulation ingredient rather than a treatment active. |
| sh-Polypeptide-123 Key active Signal peptide / growth factor mimetic | sh-Polypeptide-123 is a synthetic (recombinant/synthesized) human-identical peptide used in skincare to signal fibroblasts and support collagen and extracellular matrix production. It is marketed primarily for anti-aging and skin-repair applications. |
| Sodium Polyacrylate Thickener / absorbent | Sodium polyacrylate is a superabsorbent acrylic-acid polymer used in skincare as a thickening, stabilizing, and water-binding agent that can hold large amounts of liquid to create gel-like textures. It functions as a formulation and texture-enhancing ingredient rather than a biologically active treatment. |
| Ethylhexylglycerin Preservative booster / skin-conditioning agent | Ethylhexylglycerin is a multifunctional glyceryl ether used in cosmetics primarily as a preservative-enhancing agent and emollient, often paired with phenoxyethanol to broaden antimicrobial efficacy. It also acts as a deodorizing agent and humectant in skincare formulations. |
| Octenidine HCl Key active Antiseptic/antimicrobial | Octenidine HCl is a cationic surfactant antiseptic effective against bacteria, fungi, and some viruses, used in skin and wound disinfection and as a preservative in topical formulations. It binds to negatively charged microbial cell membranes, disrupting their integrity. |
| Phytic acid Chelating agent / antioxidant exfoliant | Phytic acid is a plant-derived compound that chelates metal ions and provides mild antioxidant and gentle exfoliating effects, often used in formulations to brighten skin and stabilize products. It is sometimes included in peels and serums as a milder alternative to traditional alpha hydroxy acids. |
| Disodium EDTA Chelating agent | Disodium EDTA is a chelating agent used in cosmetics to bind metal ions, improving product stability, preventing rancidity, and enhancing the efficacy of preservatives. It is a formulation/base ingredient rather than a treatment active. |
| Benzotriazolyl Dodecyl p-Cresol UV stabilizer/antioxidant | Benzotriazolyl Dodecyl P-Cresol is a benzotriazole-derived light stabilizer and antioxidant used in cosmetic formulations to protect product integrity by absorbing UV radiation and preventing oxidative degradation of other ingredients. It functions as a formulation-protecting additive rather than a skin treatment active. |
| Citric acid pH adjuster / AHA exfoliant | Citric acid is an alpha-hydroxy acid derived from citrus fruits, used primarily to adjust and buffer formulation pH and as a chelating agent, and at higher concentrations as a mild chemical exfoliant. It can promote surface cell turnover and is sometimes included in antioxidant or brightening products. |
| Sodium citrate pH adjuster / chelating agent | Sodium citrate is the sodium salt of citric acid used in skincare primarily as a buffering agent to stabilize formulation pH and as a chelator that binds metal ions to improve product stability. It is a base/formulation ingredient rather than a therapeutic active. |
Key active = does the main work. Ingredient explanations are drawn from public databases & literature.
Peer-reviewed papers on the active ingredients in this product, via PubMed.