Cyanocobalamin is a synthetic form of vitamin B12 used topically in skincare, where it is studied mainly for its potential to support skin barrier function and reduce inflammation, particularly in atopic dermatitis. It also acts as a colorant due to its characteristic pink-red hue.
| Reported effect | How often | Notes |
|---|---|---|
Mild skin irritation or stinging | Uncommon | Transient local irritation reported at application site. |
Contact dermatitis / allergic sensitization | Rare | Isolated cases of cutaneous hypersensitivity to cobalamin compounds. |
Temporary staining of skin or fabric | Uncommon | Due to the intense pink-red color of the molecule, not a true adverse reaction. |
Acneiform eruptions | Rare | Reported more with high-dose systemic B12; topical contribution is unclear and limited. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.