SH-Oligopeptide-2 is a synthetic peptide corresponding to insulin-like growth factor-1 (IGF-1), used in cosmetic formulations to support cell proliferation, skin repair, and anti-aging effects. It is typically incorporated into serums and creams aimed at improving skin texture and firmness.
| Reported effect | How often | Notes |
|---|---|---|
Mild localized irritation or redness | Uncommon | Transient and usually resolves after discontinuation; more likely in sensitive skin. |
Contact allergic reaction or sensitization | Rare | Possible with peptide-based actives; presents as itching or dermatitis. |
Theoretical concern regarding growth factor stimulation | Very rare | Limited long-term safety data; debated potential influence on proliferative skin processes, though not established in cosmetic use. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
Peer-reviewed papers on this ingredient, via PubMed.