Tripeptide-1 (also known as Glycyl-L-Histidyl-L-Lysine, GHK) is a signaling peptide used in anti-aging formulations to support collagen and extracellular matrix production. It is studied for improving skin firmness, elasticity, and reducing the appearance of fine lines.
| Reported effect | How often | Notes |
|---|---|---|
Mild transient irritation or redness | Uncommon | Usually mild and resolves with discontinuation or reduced frequency. |
Contact dermatitis / allergic sensitization | Rare | Possible in individuals sensitive to peptides or co-formulated ingredients. |
Stinging or tingling on application | Rare | More likely on compromised or sensitized skin barriers. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.