Below is every ingredient in Dr Sheth S Centella 10Percent Niacinamide Ampoule Serum explained, its standout actives, and the side effects reported in research for those actives — analysed for Indian skin.
Flags derived from the ingredient list using dermatology reference data (fungal-acne substrate, comedogenicity, EU allergens). General guidance, not a diagnosis.
Answers are derived from the printed ingredient list and dermatology reference data — general guidance, not a diagnosis or a therapeutic claim.
Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%.
Zinc PCA is the zinc salt of pyrrolidone carboxylic acid used in skincare to help control excess sebum, support antimicrobial activity, and provide mild hydration. It is commonly included in products targeting oily and acne-prone skin.
Centella Asiatica Extract is a plant-derived ingredient rich in triterpenoids (asiaticoside, madecassoside, asiatic and madecassic acids) used to calm inflammation, support wound healing, and strengthen the skin barrier. It is also valued for antioxidant and collagen-supporting properties in topical formulations.
Phellodendron Amurense Bark Extract is a plant-derived extract rich in berberine and other alkaloids, used in skincare for its anti-inflammatory, antioxidant, and antimicrobial properties. It is commonly included to calm irritation, balance sebum, and support acne-prone or sensitive skin.
Glycolic acid is an alpha-hydroxy acid derived from sugar cane that exfoliates by loosening bonds between dead skin cells on the surface, promoting cell turnover and improving texture, tone, and fine lines. It is one of the smallest AHAs, allowing relatively deep penetration into the skin.
Salix Alba (White Willow) Bark Extract is a botanical source of salicin, which can be converted to salicylic acid, offering mild exfoliating, anti-inflammatory, and astringent properties. It is commonly used in formulations targeting acne-prone, oily, or congested skin as a gentler alternative to synthetic salicylic acid.
Aggregated from the active ingredients in this product.
| Reported effect | How often | Notes |
|---|---|---|
| Irritation or sensitivity | Very rare | Purified water itself is essentially inert; rare reactions are attributable to contaminants or accompanying ingredients rather than water. |
| Transepidermal water loss aggravation in compromised skin | Rare | Evaporation of water from products may transiently increase dryness in very compromised skin barriers if occlusives are absent. |
| Mild transient flushing or redness | Uncommon | More likely at higher concentrations or in sensitive skin; usually subsides quickly. |
| Tingling, stinging, or burning sensation | Uncommon | Often associated with higher percentages or compromised barrier. |
| Contact irritation or itching | Rare | Generally dose-dependent and resolves with discontinuation. |
| Allergic contact dermatitis | Very rare | Documented in isolated case reports; true sensitization is unusual. |
| Mild skin irritation | Uncommon | Possible at higher concentrations, particularly on sensitive or compromised skin. |
| Enhanced irritation from co-formulated actives | Uncommon | By increasing penetration, it may intensify the effects or irritation potential of other ingredients. |
| Eye irritation | Rare | Can occur with accidental contact in concentrated form. |
| Mild skin irritation or stinging | Uncommon | Usually transient, more likely on sensitive or compromised skin. |
| Redness (erythema) | Uncommon | Typically mild and temporary at application site. |
| Dryness or skin tightness | Rare | May occur with overuse due to sebum-reducing effect. |
| Enhanced penetration of co-formulated irritants | Uncommon | As a penetration enhancer it may increase absorption and irritation potential of other actives. |
| Mild irritation or stinging | Uncommon | Transient sensation typically on sensitive or compromised skin. |
| Redness or itching | Uncommon | Localized and usually resolves with discontinuation. |
| Photosensitivity-related reaction | Very rare | Limited anecdotal reports; not well established in research. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
| Ingredient | What it does |
|---|---|
| Aqua Solvent / vehicle | Aqua (water) is the most common base ingredient in skincare formulations, serving as a solvent that dissolves water-soluble components and forms the medium for emulsions. It has no direct treatment activity and primarily contributes to texture, spreadability, and product delivery. |
| Niacinamide Key active Cell-communicating / barrier-repair active | Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%. |
| Ethoxydiglycol Solvent / penetration enhancer | Ethoxydiglycol (diethylene glycol monoethyl ether) is a glycol ether used in cosmetic formulations primarily as a solvent and viscosity reducer that helps dissolve active ingredients and improve their skin penetration. It is considered a formulation aid rather than a therapeutic active. |
| Zinc Pca Key active Sebum-regulating, antimicrobial | Zinc PCA is the zinc salt of pyrrolidone carboxylic acid used in skincare to help control excess sebum, support antimicrobial activity, and provide mild hydration. It is commonly included in products targeting oily and acne-prone skin. |
| Propanediol Humectant/solvent | Propanediol is a plant-derived glycol used in skincare as a humectant, solvent, and penetration enhancer that improves moisturization and the spreadability of formulations. It also helps solubilize other ingredients and can boost the efficacy of certain actives. |
| Centella Asiatica Extract Key active Soothing/antioxidant active | Centella Asiatica Extract is a plant-derived ingredient rich in triterpenoids (asiaticoside, madecassoside, asiatic and madecassic acids) used to calm inflammation, support wound healing, and strengthen the skin barrier. It is also valued for antioxidant and collagen-supporting properties in topical formulations. |
| Butylene Glycol Humectant / solvent | Butylene glycol is a small diol commonly used in skincare as a humectant, solvent, and viscosity-reducing agent that helps dissolve other ingredients and improve skin feel. It is widely regarded as safe and non-sensitizing for the majority of users at cosmetic concentrations. |
| Phellodendron Amurense Bark Extract Key active Soothing / anti-inflammatory botanical | Phellodendron Amurense Bark Extract is a plant-derived extract rich in berberine and other alkaloids, used in skincare for its anti-inflammatory, antioxidant, and antimicrobial properties. It is commonly included to calm irritation, balance sebum, and support acne-prone or sensitive skin. |
| Glycolic Acid Key active Chemical exfoliant (AHA) | Glycolic acid is an alpha-hydroxy acid derived from sugar cane that exfoliates by loosening bonds between dead skin cells on the surface, promoting cell turnover and improving texture, tone, and fine lines. It is one of the smallest AHAs, allowing relatively deep penetration into the skin. |
| PEG-60 Hydrogenated Castor Oil Solubilizer/emulsifier | PEG-60 Hydrogenated Castor Oil is a nonionic surfactant derived from hydrogenated castor oil reacted with ethylene oxide, widely used to solubilize fragrances, oils, and lipophilic actives into water-based cosmetic formulations. It functions as a base/formulation aid rather than a treatment active. |
| Salix Alba Bark Extract Key active Natural exfoliant / anti-inflammatory | Salix Alba (White Willow) Bark Extract is a botanical source of salicin, which can be converted to salicylic acid, offering mild exfoliating, anti-inflammatory, and astringent properties. It is commonly used in formulations targeting acne-prone, oily, or congested skin as a gentler alternative to synthetic salicylic acid. |
| Rehmannia Chinensis Root Extract Key active Soothing/antioxidant botanical extract | Rehmannia Chinensis Root Extract is derived from the root of the Rehmannia glutinosa plant and is used in skincare for its purported antioxidant, anti-inflammatory, and soothing properties. It contains compounds such as catalpol and iridoid glycosides that may help calm irritated skin. |
| Melia Azadirachta Leaf Extract Key active Soothing/antimicrobial botanical extract | Melia Azadirachta (neem) Leaf Extract is a plant-derived ingredient valued for its antioxidant, anti-inflammatory, and antimicrobial properties, often used in skincare for soothing and conditioning effects. It contains bioactive compounds such as nimbidin and flavonoids. |
| Scutellaria Baicalensis Root Extract Key active Antioxidant / soothing botanical | Scutellaria Baicalensis Root Extract is a plant-derived ingredient rich in flavonoids such as baicalin, baicalein, and wogonin, valued in skincare for its antioxidant, anti-inflammatory, and skin-soothing properties. It is commonly used to help calm irritation and protect skin against environmental oxidative stress. |
| Houttuynia Cordata Extract Key active Soothing antioxidant | Houttuynia Cordata Extract is a plant-derived ingredient used in skincare for its antioxidant, anti-inflammatory, and antimicrobial properties. It is often included to calm sensitive or acne-prone skin and reduce redness. |
| Glycine Soja Seed Extract Key active Antioxidant/conditioning | Glycine Soja (soybean) Seed Extract is a soy-derived ingredient rich in isoflavones, proteins, and fatty acids used in skincare for antioxidant, moisturizing, and skin-conditioning effects. It is also studied for brightening and anti-aging benefits attributed to its phytoestrogen and antioxidant content. |
| Lactobacillus/Pear Juice Ferment Filtrate Skin conditioning / fermented humectant | Lactobacillus/Pear Juice Ferment Filtrate is the filtrate produced by fermenting pear juice with Lactobacillus, yielding a mix of organic acids, peptides, and metabolites used as a skin-conditioning and hydrating agent. It is valued for mild humectant, antioxidant, and skin-barrier-supporting properties in cosmetic formulations. |
| Glyceryl Caprylate Emollient / antimicrobial co-preservative | Glyceryl Caprylate is a monoglyceride derived from glycerin and caprylic acid, used in skincare as an emollient, moisturizing agent, and skin-conditioning component with mild antimicrobial properties that support preservation. It is commonly employed to help stabilize formulations and reduce reliance on conventional preservatives. |
| Ethylhexylglycerin Preservative booster / skin-conditioning agent | Ethylhexylglycerin is a multifunctional glyceryl ether used in cosmetics primarily as a preservative-enhancing agent and emollient, often paired with phenoxyethanol to broaden antimicrobial efficacy. It also acts as a deodorizing agent and humectant in skincare formulations. |
| O-Cymen-5-Ol Antimicrobial preservative | O-Cymen-5-ol (also known as biosol or 4-isopropyl-3-methylphenol) is a phenolic antimicrobial agent used in cosmetics as a preservative and to inhibit odor-causing bacteria. It is effective against bacteria and fungi and is often included in deodorants, acne products, and skincare formulations. |
| Phenoxyethanol Preservative | Phenoxyethanol is a widely used broad-spectrum preservative that protects cosmetic and skincare formulations from bacterial and fungal contamination. It is typically used at concentrations up to 1% and serves as a formulation/base ingredient rather than an active treatment. |
| Chlorphenesin Preservative / antimicrobial | Chlorphenesin is a synthetic antimicrobial agent used in cosmetics and skincare as a preservative to inhibit the growth of bacteria, yeast, and mold. It is also occasionally used for its mild muscle-relaxant and antifungal properties in topical formulations. |
| Hydroxyethyl Cellulose Thickener / viscosity modifier | Hydroxyethyl cellulose is a non-ionic, water-soluble cellulose derivative used to thicken and stabilize aqueous skincare formulations and improve texture. It functions as a rheology modifier and film-forming agent rather than a biologically active treatment ingredient. |
| Disodium EDTA Chelating agent | Disodium EDTA is a chelating agent used in cosmetics to bind metal ions, improving product stability, preventing rancidity, and enhancing the efficacy of preservatives. It is a formulation/base ingredient rather than a treatment active. |
Key active = does the main work. Ingredient explanations are drawn from public databases & literature.
Peer-reviewed papers on the active ingredients in this product, via PubMed.