Below is every ingredient in Fixderma 2 Niacinamide Face Moisturizer 21 Cream 50G explained, its standout actives, and the side effects reported in research for those actives — analysed for Indian skin.
Flags derived from the ingredient list using dermatology reference data (fungal-acne substrate, comedogenicity, EU allergens). General guidance, not a diagnosis.
Answers are derived from the printed ingredient list and dermatology reference data — general guidance, not a diagnosis or a therapeutic claim.
Octocrylene is an organic (chemical) sunscreen agent that absorbs UVB and short UVA radiation, and is also used to stabilize and solubilize other UV filters such as avobenzone. It is commonly incorporated into sunscreens and daily-care products with SPF.
Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%.
Titanium dioxide is an inorganic mineral compound used primarily as a physical (mineral) sunscreen agent that reflects and scatters UV radiation, and also serves as a white pigment and opacifier in cosmetic formulations. It is broadly photostable and considered gentle, making it common in products for sensitive and pediatric skin.
Alpha arbutin is a naturally derived hydroquinone derivative that inhibits tyrosinase, reducing melanin production. It is used to address hyperpigmentation, dark spots, and uneven skin tone.
Tocopheryl acetate is a stable, esterified form of vitamin E used in skincare as an antioxidant and conditioning agent. It is converted to active tocopherol in the skin, helping protect against oxidative stress and supporting the skin barrier.
Aggregated from the active ingredients in this product.
| Reported effect | How often | Notes |
|---|---|---|
| Skin irritation | Rare | Generally well tolerated; mild irritation reported infrequently in sensitive individuals. |
| Allergic contact dermatitis | Very rare | Isolated case reports; the ester is considered a low sensitizer. |
| Comedogenicity (clogged pores) | Rare | Considered low to non-comedogenic, but possible in acne-prone skin depending on formulation. |
| Contact dermatitis / skin irritation | Uncommon | Localized redness, itching, or stinging on application. |
| Photoallergic contact dermatitis | Rare | Reported particularly in adults, sometimes linked to prior ketoprofen sensitization. |
| Systemic absorption | Common | Detectable in blood after use; clinical significance unclear and not equated with harm. |
| Benzophenone formation over time | Uncommon | Degradation can yield trace benzophenone; relevance to skin health under study. |
| Mild transient flushing or redness | Uncommon | More likely at higher concentrations or in sensitive skin; usually subsides quickly. |
| Tingling, stinging, or burning sensation | Uncommon | Often associated with higher percentages or compromised barrier. |
| Contact irritation or itching | Rare | Generally dose-dependent and resolves with discontinuation. |
| Comedogenicity (pore-clogging) | Uncommon | May contribute to clogged pores or breakouts in acne-prone or oily skin, though shea is generally low on the comedogenic scale. |
| Skin irritation or redness | Rare | Occasional mild irritation, often related to impurities in unrefined products or individual sensitivity. |
| White cast on skin | Common | Cosmetic effect, more pronounced on deeper skin tones and with non-micronized grades. |
| Skin dryness or mild irritation | Uncommon | Usually related to the overall formulation rather than the ingredient itself. |
| Contact dermatitis or allergic reaction | Rare | Titanium dioxide is a recognized low-sensitizing ingredient; reactions are infrequent. |
| Comedogenicity / clogged pores | Rare | Can occur in some individuals depending on coating and formulation base. |
| Inhalation-related respiratory concern | Very rare | Relevant only to loose powder/spray forms via inhalation, not topical leave-on use. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
| Ingredient | What it does |
|---|---|
| Isononyl Isononanoate Emollient/skin-conditioning agent | Isononyl Isononanoate is a synthetic ester emollient used in cosmetics to impart a light, silky, non-greasy skin feel and to aid the spreadability of formulations. It functions as a base/texture ingredient rather than a treatment active. |
| Octocrylene Key active UV filter | Octocrylene is an organic (chemical) sunscreen agent that absorbs UVB and short UVA radiation, and is also used to stabilize and solubilize other UV filters such as avobenzone. It is commonly incorporated into sunscreens and daily-care products with SPF. |
| Niacinamide Key active Cell-communicating / barrier-repair active | Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%. |
| Butyrospermum Parkii (Shea) Butter Emollient / occlusive moisturizer | Butyrospermum Parkii (Shea) Butter is a plant-derived fat extracted from the nuts of the African shea tree, rich in triglycerides and unsaponifiables. It is widely used in skincare to soften, smooth, and condition the skin while forming an occlusive barrier that reduces water loss. |
| Titanium Dioxide Key active UV filter / mineral sunscreen | Titanium dioxide is an inorganic mineral compound used primarily as a physical (mineral) sunscreen agent that reflects and scatters UV radiation, and also serves as a white pigment and opacifier in cosmetic formulations. It is broadly photostable and considered gentle, making it common in products for sensitive and pediatric skin. |
| Xylitylglucoside & Anhydroxylitol Humectant / moisturizing complex | Xylitylglucoside & Anhydroxylitol is a plant-derived sugar complex (often combined with xylitol) used as a humectant to attract and retain water in the skin and support the skin's natural moisturizing factors. It is valued for enhancing hydration and reinforcing the skin barrier. |
| & Xylitol Humectant/moisturizer | Xylitol is a sugar alcohol used in skincare as a humectant that helps attract and retain moisture in the skin and supports the skin's barrier and microbiome balance. It is generally well tolerated and functions as a supporting formulation ingredient rather than a primary treatment active. |
| Alpha-Arbutin Key active Skin-brightening agent | Alpha arbutin is a naturally derived hydroquinone derivative that inhibits tyrosinase, reducing melanin production. It is used to address hyperpigmentation, dark spots, and uneven skin tone. |
| Phenoxyethanol & Ethylhexylglycerin Preservative system | A widely used preservative blend in which phenoxyethanol provides broad-spectrum antimicrobial protection against bacteria, yeast, and mold, while ethylhexylglycerin acts as a skin-conditioning agent and preservative booster that enhances antimicrobial efficacy. The combination is commonly used to prevent microbial contamination and extend shelf life in cosmetic and skincare formulations. |
| Tocopheryl Acetate Key active Antioxidant | Tocopheryl acetate is a stable, esterified form of vitamin E used in skincare as an antioxidant and conditioning agent. It is converted to active tocopherol in the skin, helping protect against oxidative stress and supporting the skin barrier. |
| Phytic Acid Chelating agent / antioxidant exfoliant | Phytic acid is a plant-derived compound that chelates metal ions and provides mild antioxidant and gentle exfoliating effects, often used in formulations to brighten skin and stabilize products. It is sometimes included in peels and serums as a milder alternative to traditional alpha hydroxy acids. |
| Fragrance Fragrance/masking agent | Fragrance refers to a blend of natural or synthetic aromatic compounds added to skincare products to impart a pleasant scent or mask the odor of other ingredients. It serves a sensory and formulation purpose rather than a therapeutic one. |
Key active = does the main work. Ingredient explanations are drawn from public databases & literature.
Peer-reviewed papers on the active ingredients in this product, via PubMed.