Beta-caryophyllene is a plant-derived sesquiterpene found in essential oils such as clove, black pepper, and copaiba, valued in skincare for its anti-inflammatory and antioxidant properties, partly mediated through CB2 cannabinoid receptor activity. It is used to help calm irritated skin and support the skin's defense against oxidative stress.
| Reported effect | How often | Notes |
|---|---|---|
Contact allergy / sensitization | Uncommon | As a fragrance terpene, it can act as a contact allergen, especially after oxidation upon air exposure. |
Skin irritation | Uncommon | May cause mild redness or irritation, particularly at higher concentrations or in sensitive skin. |
Oxidation-related reactivity | Rare | Degradation products from oxidized terpenes may increase allergenic potential over time. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.