Palmitoyl Tripeptide-38 is a synthetic lipopeptide (also known by the trade name Matrixyl synthe'6) that signals fibroblasts to boost production of collagen, elastin, hyaluronic acid, and other dermal matrix components. It is used in topical formulations to help reduce the appearance of fine lines and wrinkles and improve skin texture.
| Reported effect | How often | Notes |
|---|---|---|
| Mild transient irritation or redness | Rare | Generally well tolerated; minor stinging may occur in sensitive skin or at higher concentrations. |
| Contact dermatitis or allergic reaction | Very rare | Isolated sensitivity possible, often related to other formulation components rather than the peptide itself. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.