Below is every ingredient in Hyphen Acne Defence Daily Serum explained, its standout actives, and the side effects reported in research for those actives — analysed for Indian skin.
Flags derived from the ingredient list using dermatology reference data (fungal-acne substrate, comedogenicity, EU allergens). General guidance, not a diagnosis.
Answers are derived from the printed ingredient list and dermatology reference data — general guidance, not a diagnosis or a therapeutic claim.
Azelaic acid is a naturally occurring dicarboxylic acid used topically to treat acne and rosacea, working through antibacterial, anti-inflammatory, and comedolytic actions. It also inhibits tyrosinase, helping reduce hyperpigmentation.
Centella Asiatica Extract is a plant-derived ingredient rich in triterpenoids (asiaticoside, madecassoside, asiatic and madecassic acids) used to calm inflammation, support wound healing, and strengthen the skin barrier. It is also valued for antioxidant and collagen-supporting properties in topical formulations.
Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%.
Salicylic acid is a lipid-soluble beta-hydroxy acid that exfoliates the skin surface and penetrates sebaceous pores to loosen and dissolve keratin and debris. It is widely used to treat acne, blackheads, and conditions involving thickened or scaly skin.
Melaleuca Alternifolia Leaf Extract, derived from the tea tree plant, is valued for its antimicrobial, antifungal, and anti-inflammatory properties and is commonly used in formulations targeting acne and minor skin irritations. Its activity is largely attributed to terpinen-4-ol and related terpene compounds.
Aggregated from the active ingredients in this product.
| Reported effect | How often | Notes |
|---|---|---|
| Irritation or sensitivity | Very rare | Purified water itself is essentially inert; rare reactions are attributable to contaminants or accompanying ingredients rather than water. |
| Transepidermal water loss aggravation in compromised skin | Rare | Evaporation of water from products may transiently increase dryness in very compromised skin barriers if occlusives are absent. |
| Mild skin irritation | Uncommon | Transient stinging or redness, more likely on compromised or sensitive skin. |
| Allergic contact dermatitis | Rare | Sensitization is infrequent; propanediol is generally considered low-risk for allergy. |
| Enhanced penetration of co-formulated irritants | Uncommon | As a penetration enhancer it may increase absorption and irritation potential of other actives. |
| Burning, stinging, or tingling | Common | Usually mild and transient, often during initial weeks of use |
| Itching (pruritus) | Common | Localized to application site |
| Dryness, scaling, or peeling | Common | Mild local irritation |
| Erythema (redness) | Uncommon | Application-site redness that typically subsides |
| Contact dermatitis | Rare | Allergic or irritant reaction requiring discontinuation |
| Hypopigmentation | Rare | More likely on darker skin tones; lightening of treated skin |
| Worsening of asthma | Very rare | Reported in isolated cases following topical use |
| Mild irritation or stinging | Uncommon | Transient sensation typically on sensitive or compromised skin. |
| Redness or itching | Uncommon | Localized and usually resolves with discontinuation. |
| Photosensitivity-related reaction | Very rare | Limited anecdotal reports; not well established in research. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
| Ingredient | What it does |
|---|---|
| Aqua Solvent / vehicle | Aqua (water) is the most common base ingredient in skincare formulations, serving as a solvent that dissolves water-soluble components and forms the medium for emulsions. It has no direct treatment activity and primarily contributes to texture, spreadability, and product delivery. |
| Propanediol Humectant/solvent | Propanediol is a plant-derived glycol used in skincare as a humectant, solvent, and penetration enhancer that improves moisturization and the spreadability of formulations. It also helps solubilize other ingredients and can boost the efficacy of certain actives. |
| Azelaic Acid Key active Anti-inflammatory / keratolytic active | Azelaic acid is a naturally occurring dicarboxylic acid used topically to treat acne and rosacea, working through antibacterial, anti-inflammatory, and comedolytic actions. It also inhibits tyrosinase, helping reduce hyperpigmentation. |
| Centella Asiatica Extract Key active Soothing/antioxidant active | Centella Asiatica Extract is a plant-derived ingredient rich in triterpenoids (asiaticoside, madecassoside, asiatic and madecassic acids) used to calm inflammation, support wound healing, and strengthen the skin barrier. It is also valued for antioxidant and collagen-supporting properties in topical formulations. |
| Triethanolamine pH adjuster / emulsifier | Triethanolamine is an organic compound used in cosmetic formulations primarily to adjust pH and to act as an emulsifying agent, helping to stabilize mixtures of oil and water. It is typically present in small concentrations as a formulation aid rather than a therapeutic active. |
| Niacinamide Key active Cell-communicating / barrier-repair active | Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%. |
| 1,2-Hexanediol Humectant / preservative booster | 1,2-Hexanediol is a synthetic diol used in skincare as a humectant and solvent that also enhances the antimicrobial efficacy of formulations, often allowing reduced or preservative-free systems. It helps maintain product stability while contributing mild moisturizing properties. |
| Pentylene Glycol Humectant / solvent / preservative-booster | Pentylene glycol is a glycol used in cosmetics as a humectant and solvent that also enhances the antimicrobial efficacy of formulations, helping reduce reliance on traditional preservatives. It improves skin hydration and aids the delivery and stability of other ingredients. |
| Salicylic Acid Key active Beta-hydroxy acid (BHA) exfoliant / keratolytic | Salicylic acid is a lipid-soluble beta-hydroxy acid that exfoliates the skin surface and penetrates sebaceous pores to loosen and dissolve keratin and debris. It is widely used to treat acne, blackheads, and conditions involving thickened or scaly skin. |
| Melaleuca Alternifolia Leaf Extract Key active Antimicrobial/anti-inflammatory botanical | Melaleuca Alternifolia Leaf Extract, derived from the tea tree plant, is valued for its antimicrobial, antifungal, and anti-inflammatory properties and is commonly used in formulations targeting acne and minor skin irritations. Its activity is largely attributed to terpinen-4-ol and related terpene compounds. |
| Sodium Gluconate Chelating agent / skin-conditioning | Sodium gluconate is the sodium salt of gluconic acid used in skincare primarily as a chelating agent to bind metal ions and stabilize formulations, with secondary humectant and skin-conditioning properties. It is generally considered a base/formulation ingredient rather than an active treatment. |
| Xanthan Gum Thickener/stabilizer | Xanthan gum is a polysaccharide produced by bacterial fermentation, used in skincare as a thickening, gelling, and emulsion-stabilizing agent. It improves product texture and suspension of ingredients without contributing active treatment effects. |
| Sodium Citrate pH adjuster / chelating agent | Sodium citrate is the sodium salt of citric acid used in skincare primarily as a buffering agent to stabilize formulation pH and as a chelator that binds metal ions to improve product stability. It is a base/formulation ingredient rather than a therapeutic active. |
| Sodium Hydroxide pH adjuster | Sodium hydroxide (lye) is a strong alkaline compound used in small amounts to adjust and stabilize the pH of cosmetic formulations. At regulated low concentrations in finished products it is considered safe, though it is corrosive in concentrated form. |
| Phenoxyethanol Preservative | Phenoxyethanol is a widely used broad-spectrum preservative that protects cosmetic and skincare formulations from bacterial and fungal contamination. It is typically used at concentrations up to 1% and serves as a formulation/base ingredient rather than an active treatment. |
| Ethylhexylglycerin Preservative booster / skin-conditioning agent | Ethylhexylglycerin is a multifunctional glyceryl ether used in cosmetics primarily as a preservative-enhancing agent and emollient, often paired with phenoxyethanol to broaden antimicrobial efficacy. It also acts as a deodorizing agent and humectant in skincare formulations. |
Key active = does the main work. Ingredient explanations are drawn from public databases & literature.
Peer-reviewed papers on the active ingredients in this product, via PubMed.