Thedermaco · 🇮🇳 India

0.3% Retinol Serum - 30ml

28 ingredients
What's in it

Below is every ingredient in 0.3% Retinol Serum - 30ml explained, its standout actives, and the side effects reported in research for those actives — analysed for Indian skin.

Suitability at a glance — for Indian skin

🍄 May trigger fungal acne
3 ingredient(s) can feed Malassezia — relevant in humid Indian weather
Pore-clogging risk: Low
Highest comedogenic rating 0/5 — matters for oily, acne-prone skin
Contains fragrance / allergens
Fragrance
Pregnancy: use caution
Retinol — discuss with a doctor

Flags derived from the ingredient list using dermatology reference data (fungal-acne substrate, comedogenicity, EU allergens). General guidance, not a diagnosis.

Your questions, answered from the ingredient list

Is 0.3% Retinol Serum - 30ml fungal-acne safe?
Based on its listed ingredients, 0.3% Retinol Serum - 30ml contains 3 ingredient(s) reported to feed Malassezia (the yeast behind fungal acne): Methyl Glucose Sesquistearate, Pentaerythrityl Distearate, Polysorbate 20. If you are fungal-acne prone, you may want to avoid these.
Does 0.3% Retinol Serum - 30ml contain fragrance?
Yes — 0.3% Retinol Serum - 30ml lists Fragrance, which are fragrance ingredients or EU-declared allergens. Relevant if your skin is sensitive or reactive.
Will 0.3% Retinol Serum - 30ml clog pores?
The highest comedogenic rating among its listed ingredients is 0/5 (low). Comedogenicity matters most for oily, acne-prone skin in humid Indian weather; it is a property of ingredients in lab tests, not a guarantee either way.
Is 0.3% Retinol Serum - 30ml safe to use in pregnancy?
0.3% Retinol Serum - 30ml contains 1 ingredient(s) commonly flagged for caution in pregnancy in published guidance: Retinol. Discuss with your doctor before using it while pregnant or breastfeeding.

Answers are derived from the printed ingredient list and dermatology reference data — general guidance, not a diagnosis or a therapeutic claim.

Key actives

Dimethylmethoxy Chromanol
Antioxidant

Dimethylmethoxy Chromanol is a synthetic chroman-derived antioxidant (a vitamin E-related molecule) used in cosmetic formulations to neutralize free radicals and protect skin and product stability against oxidative damage. It is marketed for both lipophilic and hydrophilic environments, offering broad-spectrum protection against reactive oxygen and nitrogen species.

Tetrahexyldecyl Ascorbate
Antioxidant / Vitamin C derivative

Tetrahexyldecyl Ascorbate is a stable, oil-soluble derivative of vitamin C used as an antioxidant that can be converted to ascorbic acid in the skin, supporting collagen synthesis and helping reduce signs of photoaging and hyperpigmentation. It is favored for its stability and ability to penetrate the skin's lipid barrier compared with pure ascorbic acid.

Physalis Angulata Extract
Antioxidant/soothing botanical extract

Physalis Angulata Extract is a plant-derived ingredient used in skincare for its antioxidant, anti-inflammatory, and skin-conditioning properties, often included to help calm and protect the skin. It contains compounds such as physalins and flavonoids that may help mitigate oxidative stress.

4-T-Butylcyclohexanol
Soothing/anti-irritant agent (TRPV1 antagonist)

4-T-Butylcyclohexanol is a synthetic cyclohexanol derivative used in skincare to reduce sensory irritation and redness by inhibiting the TRPV1 receptor. It is commonly added to formulations for sensitive or reactive skin to counteract irritation from other actives.

Retinol
Vitamin A derivative / anti-aging active

Retinol is a vitamin A derivative that converts to retinoic acid in the skin, promoting cell turnover and stimulating collagen synthesis. It is widely used to address fine lines, photoaging, and acne.

Side effects reported in research

Aggregated from the active ingredients in this product.

Reported effectHow oftenNotes
Irritation or sensitivityVery rarePurified water itself is essentially inert; rare reactions are attributable to contaminants or accompanying ingredients rather than water.
Transepidermal water loss aggravation in compromised skinRareEvaporation of water from products may transiently increase dryness in very compromised skin barriers if occlusives are absent.
Skin irritationRareGenerally well tolerated; mild irritation possible in sensitive individuals.
Allergic contact dermatitisVery rareSensitization is uncommon; isolated reports only.
Eye irritationRarePossible transient stinging if product enters the eyes.
Mild transient stinging or irritationUncommonMore likely at high concentrations or on compromised/broken skin.
Tacky or sticky skin feelCommonA cosmetic sensation rather than an adverse reaction, more noticeable at higher concentrations.
Contact dermatitis or allergic reactionRareTrue allergy to glycerin is uncommon; patch-test positivity is infrequent.
Skin dehydration in very low humidityRareIn very dry environments humectants may draw water from deeper skin layers if not paired with an occlusive.
Mild irritation or rednessRareOccasional sensitivity reported in susceptible individuals; generally well tolerated at typical use concentrations.
Contact allergy or sensitizationVery rareIsolated reports; limited data on long-term sensitization potential.
Contact urticariaVery rareRarely reported immediate hypersensitivity reaction.
Mild skin irritationUncommonTransient stinging or redness, more likely at higher concentrations or on compromised skin.
Skin drynessUncommonIts solvent action may contribute to dryness with repeated use in some individuals.
Systemic toxicityVery rareOf theoretical concern with large-scale ingestion or extreme exposure; not associated with normal topical cosmetic use.

Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.

Full ingredient breakdown

IngredientWhat it does
Aqua
Solvent / vehicle
Aqua (water) is the most common base ingredient in skincare formulations, serving as a solvent that dissolves water-soluble components and forms the medium for emulsions. It has no direct treatment activity and primarily contributes to texture, spreadability, and product delivery.
Diethylhexyl Carbonate
Emollient / solvent
Diethylhexyl Carbonate is a lightweight synthetic ester (dialkyl carbonate) used as an emollient and solvent in skincare and cosmetics. It imparts a smooth, dry, non-greasy skin feel and helps dissolve and spread other ingredients such as UV filters and active oils.
Glycerin
Humectant
Glycerin is a widely used humectant that attracts and retains water in the skin, helping to hydrate the stratum corneum and support barrier function. It is considered safe and well-tolerated across most skin types and concentrations.
Dimethylmethoxy Chromanol Key active
Antioxidant
Dimethylmethoxy Chromanol is a synthetic chroman-derived antioxidant (a vitamin E-related molecule) used in cosmetic formulations to neutralize free radicals and protect skin and product stability against oxidative damage. It is marketed for both lipophilic and hydrophilic environments, offering broad-spectrum protection against reactive oxygen and nitrogen species.
Ethylhexyl Methoxycrylene
Photostabilizer / UV filter solubilizer
Ethylhexyl Methoxycrylene is a synthetic ingredient used in sunscreens to stabilize UV filters such as avobenzone and octinoxate, preventing their photodegradation upon sun exposure. It also acts as a solvent that helps dissolve other UV-absorbing compounds in the formulation.
Diethylene Glycol Monoethyl Ether
Solvent / penetration enhancer
Diethylene glycol monoethyl ether (ethoxydiglycol) is a versatile solvent and penetration enhancer used in cosmetic and topical formulations to dissolve active ingredients and improve their absorption into the skin. It also functions as a viscosity reducer and coupling agent in mixed-phase products.
Tetrahexyldecyl Ascorbate Key active
Antioxidant / Vitamin C derivative
Tetrahexyldecyl Ascorbate is a stable, oil-soluble derivative of vitamin C used as an antioxidant that can be converted to ascorbic acid in the skin, supporting collagen synthesis and helping reduce signs of photoaging and hyperpigmentation. It is favored for its stability and ability to penetrate the skin's lipid barrier compared with pure ascorbic acid.
Physalis Angulata Extract Key active
Antioxidant/soothing botanical extract
Physalis Angulata Extract is a plant-derived ingredient used in skincare for its antioxidant, anti-inflammatory, and skin-conditioning properties, often included to help calm and protect the skin. It contains compounds such as physalins and flavonoids that may help mitigate oxidative stress.
Caprylic/Capric Triglyceride
Emollient / skin-conditioning agent
Caprylic/Capric Triglyceride is a lightweight emollient derived from coconut or palm oil and glycerin, used to soften skin, improve spreadability, and act as a solvent for oil-soluble ingredients. It is well-tolerated and serves primarily as a base ingredient rather than an active.
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
Emulsifier/stabilizer (thickener)
Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer is a synthetic acrylate-based polymer used to thicken, stabilize, and emulsify cosmetic formulations, creating smooth gel and cream textures. It is widely employed as a rheology modifier and is not a therapeutic active.
Cyclopentasiloxane
Emollient/silicone
Cyclopentasiloxane is a volatile cyclic silicone widely used in skincare and cosmetics to impart a smooth, silky feel and spreadability before evaporating, leaving no greasy residue. It also serves as a carrier and helps reduce tackiness in formulations.
Phenyl Trimethicone
Silicone emollient/conditioning agent
Phenyl Trimethicone is a phenyl-substituted silicone used in skincare and cosmetics to impart a smooth, silky feel, add shine, and provide water-repellent film-forming and conditioning properties. It functions as a formulation/base ingredient rather than a treatment active.
Dimethiconol
Emollient/silicone conditioning agent
Dimethiconol is a silicone-based polymer used in skincare and haircare to provide smoothing, conditioning, and a soft, non-greasy emollient feel. It forms a thin, breathable film that reduces moisture loss and improves spreadability of formulations.
C12-15 Alkyl Benzoate
Emollient / texture enhancer
C12-15 Alkyl Benzoate is a lightweight ester emollient widely used in skincare and cosmetics to improve spreadability, provide a smooth non-greasy skin feel, and act as a solvent and mild antimicrobial booster. It is considered a base/formulation ingredient rather than a treatment active.
Dimethicone Crosspolymer
Silicone-based texture enhancer/film former
Dimethicone Crosspolymer is a crosslinked silicone polymer used in skincare and cosmetics to provide a smooth, silky feel, absorb excess oil, blur the appearance of pores and fine lines, and improve product spreadability. It functions as a formulation ingredient rather than a therapeutic active.
Phenoxyethanol
Preservative
Phenoxyethanol is a widely used broad-spectrum preservative that protects cosmetic and skincare formulations from bacterial and fungal contamination. It is typically used at concentrations up to 1% and serves as a formulation/base ingredient rather than an active treatment.
Ethylhexylglycerin
Preservative booster / skin-conditioning agent
Ethylhexylglycerin is a multifunctional glyceryl ether used in cosmetics primarily as a preservative-enhancing agent and emollient, often paired with phenoxyethanol to broaden antimicrobial efficacy. It also acts as a deodorizing agent and humectant in skincare formulations.
Behenyl Alcohol
Emollient / Thickener
Behenyl alcohol is a fatty alcohol derived from behenic acid that functions as an emollient, thickening agent, and emulsion stabilizer in cosmetic and skincare formulations. It helps soften the skin and improve product texture and stability.
Methyl Glucose Sesquistearate
Emulsifier / emollient
Methyl Glucose Sesquistearate is a glucose-derived nonionic emulsifier used to stabilize oil-in-water emulsions and impart a smooth, conditioning skin feel. It is considered mild and is widely used as a formulation base ingredient rather than a treatment active.
Trisodium Ethylenediamine Disuccinate
Chelating agent
Trisodium Ethylenediamine Disuccinate (Trisodium Ethylenediamine Disuccinate, or HEDTA-type biodegradable chelator) is a biodegradable chelating agent used to bind metal ions in cosmetic formulations. By sequestering trace metals, it helps stabilize products, prevent discoloration and rancidity, and enhance the efficacy of preservatives and antioxidants.
Pentaerythrityl Distearate
Emollient / thickener
Pentaerythrityl Distearate is an ester of pentaerythritol and stearic acid used as an emollient, viscosity-modifier and texture enhancer in cosmetic formulations. It imparts a smooth, conditioning feel and helps stabilize emulsions.
Pentylene Glycol
Humectant / solvent / preservative-booster
Pentylene glycol is a glycol used in cosmetics as a humectant and solvent that also enhances the antimicrobial efficacy of formulations, helping reduce reliance on traditional preservatives. It improves skin hydration and aids the delivery and stability of other ingredients.
4-T-Butylcyclohexanol Key active
Soothing/anti-irritant agent (TRPV1 antagonist)
4-T-Butylcyclohexanol is a synthetic cyclohexanol derivative used in skincare to reduce sensory irritation and redness by inhibiting the TRPV1 receptor. It is commonly added to formulations for sensitive or reactive skin to counteract irritation from other actives.
Butylhydroxytoluene
Antioxidant/preservative
Butylhydroxytoluene (BHT) is a synthetic phenolic antioxidant used in cosmetics to prevent oxidative degradation of oils, fragrances, and other ingredients, thereby extending product shelf life. It is a formulation stabilizer rather than a skin-treatment active.
Sodium Metabisulfite
Antioxidant/preservative
Sodium metabisulfite is an inorganic salt used in cosmetic and topical formulations primarily as an antioxidant and preservative to prevent oxidation and discoloration of products. It releases sulfur dioxide, which helps stabilize sensitive ingredients.
Retinol Key active
Vitamin A derivative / anti-aging active
Retinol is a vitamin A derivative that converts to retinoic acid in the skin, promoting cell turnover and stimulating collagen synthesis. It is widely used to address fine lines, photoaging, and acne.
Polysorbate 20
Emulsifier / solubilizer
Polysorbate 20 is a nonionic surfactant derived from sorbitol and lauric acid, used in skincare to solubilize fragrances and essential oils and to stabilize oil-in-water emulsions. It functions primarily as a formulation aid rather than a treatment active.
Fragrance
Fragrance/masking agent
Fragrance refers to a blend of natural or synthetic aromatic compounds added to skincare products to impart a pleasant scent or mask the odor of other ingredients. It serves a sensory and formulation purpose rather than a therapeutic one.

Key active = does the main work. Ingredient explanations are drawn from public databases & literature.

From published literature

Peer-reviewed papers on the active ingredients in this product, via PubMed.

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