Sh-Oligopeptide-1 is a synthetic peptide identical to human epidermal growth factor (EGF) that signals fibroblasts and keratinocytes to support cell proliferation, wound healing, and collagen synthesis. It is used in anti-aging and skin-repair formulations to improve texture, firmness, and barrier recovery.
| Reported effect | How often | Notes |
|---|---|---|
Mild transient irritation or redness | Uncommon | May occur at application site, usually self-resolving. |
Contact sensitization or allergic reaction | Rare | Possible with peptide or formulation excipients; patch testing advised for sensitive skin. |
Stinging or itching | Rare | Typically minor and short-lived. |
Theoretical concern over growth factor stimulation | Very rare | Limited data; caution sometimes advised for individuals with active skin lesions or history of skin cancer, though topical penetration of intact peptide is low. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.