Protease is a proteolytic enzyme used in skincare to break down peptide bonds in the proteins of the stratum corneum, promoting gentle exfoliation of dead surface skin cells. It is valued as an alternative to acid-based or physical exfoliation.
| Reported effect | How often | Notes |
|---|---|---|
Mild transient erythema or stinging | Common | Temporary irritation after application, especially on sensitive skin. |
Dryness or tightness | Uncommon | May occur with overuse or high enzyme concentrations. |
Contact irritant dermatitis | Uncommon | More likely with prolonged contact or compromised skin barrier. |
Allergic contact dermatitis or sensitization | Rare | Enzymes are recognized potential sensitizers and may provoke immune responses. |
Respiratory sensitization (occupational exposure) | Rare | Reported mainly with airborne enzyme dust in manufacturing, not typical consumer use. |
Severe hypersensitivity or anaphylactoid reaction | Very rare | Isolated reports in highly sensitized individuals. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.