SH-Polypeptide-1 is a synthetic or recombinant form of basic fibroblast growth factor (bFGF/FGF-2) used in skincare to stimulate fibroblast activity, collagen synthesis, and skin repair. It is typically included in anti-aging and wound-healing formulations to support dermal regeneration.
| Reported effect | How often | Notes |
|---|---|---|
Mild skin irritation or redness | Uncommon | Transient erythema or stinging at the application site, usually resolving quickly. |
Contact sensitization or allergic reaction | Rare | Localized itching, rash, or dermatitis in predisposed individuals. |
Acneiform breakouts | Rare | Possible in some users, partly attributed to formulation base rather than the peptide itself. |
Theoretical concern regarding cell proliferation | Very rare | Growth factors are debated for use on skin with active or history of cancerous/precancerous lesions; clinical evidence is limited. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.