Below is every ingredient in Cetaphil Optimal Hydration Replenishing Night Cream With Hyaluronic Acid For Dehyd explained, its standout actives, and the side effects reported in research for those actives — analysed for Indian skin.
Flags derived from the ingredient list using dermatology reference data (fungal-acne substrate, comedogenicity, EU allergens). General guidance, not a diagnosis.
Answers are derived from the printed ingredient list and dermatology reference data — general guidance, not a diagnosis or a therapeutic claim.
Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%.
Globularia Alypum Leaf Extract is a botanical ingredient derived from the leaves of the Globularia alypum shrub, used in skincare for its antioxidant and soothing properties attributed to phenolic and iridoid compounds. It is typically included to support skin conditioning and protect against oxidative stress.
Tocopherol (vitamin E) is a lipid-soluble antioxidant used in skincare to protect skin and formulations from oxidative damage caused by free radicals and UV exposure. It also functions as a skin-conditioning and emollient agent and can stabilize oils against rancidity.
Aggregated from the active ingredients in this product.
| Reported effect | How often | Notes |
|---|---|---|
| Mild skin irritation | Rare | Generally well tolerated; occasional transient redness or irritation in sensitive individuals. |
| Contact dermatitis / allergic reaction | Very rare | Isolated reports; considered a low-sensitizing ingredient. |
| Comedogenicity (pore clogging) | Rare | Low comedogenic potential, but possible in acne-prone skin at high concentrations. |
| Mild transient stinging or irritation | Uncommon | More likely at high concentrations or on compromised/broken skin. |
| Tacky or sticky skin feel | Common | A cosmetic sensation rather than an adverse reaction, more noticeable at higher concentrations. |
| Contact dermatitis or allergic reaction | Rare | True allergy to glycerin is uncommon; patch-test positivity is infrequent. |
| Skin dehydration in very low humidity | Rare | In very dry environments humectants may draw water from deeper skin layers if not paired with an occlusive. |
| Mild contact irritation | Rare | Occasional redness or stinging, usually in sensitive or compromised skin. |
| Allergic contact dermatitis | Very rare | Isolated case reports; considered a low-sensitizing ingredient. |
| Comedogenicity / clogged pores | Rare | Generally low comedogenic potential, but acne-prone individuals may occasionally react. |
| Skin irritation | Rare | Mild transient irritation possible in sensitive individuals, generally low irritation potential. |
| Mild eye irritation | Uncommon | Can cause stinging on direct ocular contact in concentrated form. |
| Cross-reactivity with other fatty alcohols | Rare | Individuals sensitized to cetyl or stearyl alcohol may react to the blend. |
| Mild transient flushing or redness | Uncommon | More likely at higher concentrations or in sensitive skin; usually subsides quickly. |
| Tingling, stinging, or burning sensation | Uncommon | Often associated with higher percentages or compromised barrier. |
| Contact irritation or itching | Rare | Generally dose-dependent and resolves with discontinuation. |
Frequencies reflect typical cosmetic use reported in the literature, not a guarantee for your skin.
| Ingredient | What it does |
|---|---|
| Dicaprylyl Carbonate Emollient / texture enhancer | Dicaprylyl Carbonate is a lightweight, non-greasy emollient derived from coconut-based fatty alcohols and carbonic acid, used to improve skin feel and spreadability in cosmetic formulations. It also acts as a solvent and helps distribute pigments and other ingredients evenly. |
| Glycerin Humectant | Glycerin is a widely used humectant that attracts and retains water in the skin, helping to hydrate the stratum corneum and support barrier function. It is considered safe and well-tolerated across most skin types and concentrations. |
| Caprylic/Capric Triglyceride Emollient / skin-conditioning agent | Caprylic/Capric Triglyceride is a lightweight emollient derived from coconut or palm oil and glycerin, used to soften skin, improve spreadability, and act as a solvent for oil-soluble ingredients. It is well-tolerated and serves primarily as a base ingredient rather than an active. |
| Glyceryl Stearate Citrate Emulsifier / co-emulsifier | Glyceryl Stearate Citrate is a plant-derived ester of glycerin, stearic acid, and citric acid used to create stable oil-in-water emulsions. It functions as a non-ionic emulsifier and skin-conditioning agent in creams and lotions. |
| Cetearyl Alcohol Emollient/emulsifier | Cetearyl alcohol is a fatty alcohol blend (cetyl and stearyl alcohol) used in skincare as an emollient, emulsion stabilizer, and thickening agent. It helps soften skin and keep oil and water phases blended in creams and lotions. |
| Niacinamide Key active Cell-communicating / barrier-repair active | Niacinamide (vitamin B3) is a water-soluble active that supports the skin barrier, regulates sebum, brightens hyperpigmentation, and reduces inflammation. It is widely tolerated across skin types and used in concentrations commonly ranging from 2% to 10%. |
| Anhydroxylitol Humectant / moisturizing agent | Anhydroxylitol is a sugar-derived (xylitol) humectant used in skincare to attract and retain water, helping to maintain skin hydration and barrier function. It is often combined with xylitol and xylitylglucoside to enhance the skin's natural moisturizing factors. |
| Butyrospermum Parkii Oil Emollient / skin-conditioning | Butyrospermum Parkii Oil is the oil fraction derived from shea (Butyrospermum parkii) seeds, valued for its emollient and occlusive properties. It is rich in fatty acids and unsaponifiables that help soften skin and reinforce the skin barrier. |
| Citric Acid pH adjuster / AHA exfoliant | Citric acid is an alpha-hydroxy acid derived from citrus fruits, used primarily to adjust and buffer formulation pH and as a chelating agent, and at higher concentrations as a mild chemical exfoliant. It can promote surface cell turnover and is sometimes included in antioxidant or brightening products. |
| Globularia Alypum Leaf Extract Key active Plant extract / antioxidant | Globularia Alypum Leaf Extract is a botanical ingredient derived from the leaves of the Globularia alypum shrub, used in skincare for its antioxidant and soothing properties attributed to phenolic and iridoid compounds. It is typically included to support skin conditioning and protect against oxidative stress. |
| Hydrolyzed Hyaluronic Acid Humectant / moisturizer | Hydrolyzed hyaluronic acid is a low-molecular-weight form of hyaluronic acid broken into smaller fragments, allowing better penetration into the skin to bind water and improve hydration. It is widely used in moisturizers and serums to enhance skin moisture content and surface smoothness. |
| Panthenol Humectant / skin-conditioning agent | Panthenol (provitamin B5) is converted to pantothenic acid in the skin, where it acts as a humectant and helps support skin barrier function and hydration. It is also used for its soothing and mild anti-inflammatory properties in topical formulations. |
| Pantolactone Humectant / conditioning agent | Pantolactone is a lactone derivative of pantothenic acid (provitamin B5) used in skincare as a moisturizing and skin-conditioning ingredient. It can serve as a precursor to panthenol and helps support skin hydration and barrier function. |
| Phenoxyethanol Preservative | Phenoxyethanol is a widely used broad-spectrum preservative that protects cosmetic and skincare formulations from bacterial and fungal contamination. It is typically used at concentrations up to 1% and serves as a formulation/base ingredient rather than an active treatment. |
| Sodium Benzoate Preservative | Sodium benzoate is a salt of benzoic acid used as a preservative in cosmetic and skincare formulations to inhibit the growth of bacteria, yeast, and fungi, particularly in acidic products. It is most effective at a pH below 5. |
| Sodium Polyacrylate Thickener / absorbent | Sodium polyacrylate is a superabsorbent acrylic-acid polymer used in skincare as a thickening, stabilizing, and water-binding agent that can hold large amounts of liquid to create gel-like textures. It functions as a formulation and texture-enhancing ingredient rather than a biologically active treatment. |
| Squalane Emollient / occlusive moisturizer | Squalane is a saturated, stable hydrocarbon derived from squalene (sourced from plants like olives or sugarcane, or shark liver) used as a lightweight emollient that softens skin and reinforces the skin barrier by reducing transepidermal water loss. It is well tolerated, non-comedogenic for most users, and serves as a base or carrier ingredient rather than a therapeutic active. |
| Tocopherol Key active Antioxidant | Tocopherol (vitamin E) is a lipid-soluble antioxidant used in skincare to protect skin and formulations from oxidative damage caused by free radicals and UV exposure. It also functions as a skin-conditioning and emollient agent and can stabilize oils against rancidity. |
| Xylitol Humectant / moisturizer | Xylitol is a sugar alcohol used in topical formulations as a humectant that helps attract and retain moisture in the skin, and it may support the skin's microbiome and barrier function. It is generally well tolerated and considered safe for topical use. |
| Xylitylglucoside Humectant / moisturizer | Xylitylglucoside is a sugar-derived humectant, typically used in combination with anhydroxylitol and xylitol, that helps attract and retain water in the skin and supports the skin barrier. It is valued for its skin-hydrating and moisturizing properties in cosmetic formulations. |
Key active = does the main work. Ingredient explanations are drawn from public databases & literature.
Peer-reviewed papers on the active ingredients in this product, via PubMed.